Why Immediate-Release Transmucosal Fentanyl Works
Sublingual Mucosal Administration
Blood-rich mucosal surfaces and passive diffusion into the lipoidal membrane provide the following benefits:
- Enables rapid absorption due to area of increased permeability
- Enables rapid drug transport to the systemic circulation
- Avoids first-pass hepatic metabolism
*The route of administration may impact the rate and extent of absorption, however a correlation to clinical effect has not been established.